Hypothalamic Tanycytes: Gatekeepers to Metabolic Control
نویسندگان
چکیده
منابع مشابه
The role of tanycytes in hypothalamic glucosensing
Tanycytes are elongated hypothalamic glial cells that cover the basal walls of the third ventricle; their apical regions contact the cerebrospinal fluid (CSF), and their processes reach hypothalamic neuronal nuclei that control the energy status of an organism. These nuclei maintain the balance between energy expenditure and intake, integrating several peripheral signals and triggering cellular...
متن کاملATP-mediated glucosensing by hypothalamic tanycytes
The brain plays a vital role in the regulation of food intake, appetite and ultimately body weight.Neurons in the hypothalamic arcuate nucleus, the ventromedial hypothalamic nuclei(VMH)and the lateral hypothalamus are sensitive to a number of circulating signals such as leptin, grehlin, insulin and glucose. These neurons are part of a network that integrates this information to regulate feeding...
متن کاملHypothalamic tanycytes—masters and servants of metabolic, neuroendocrine, and neurogenic functions
There is a resurgent interest in tanycytes, a radial glial-like cell population occupying the floor and ventro-lateral walls of the third ventricle (3V). Tanycytes reside in close proximity to hypothalamic neuronal nuclei that regulate appetite and energy expenditure, with a subset sending projections into these nuclei. Moreover, tanycytes are exposed to 3V cerebrospinal fluid and have privileg...
متن کاملAmino acid sensing in hypothalamic tanycytes via umami taste receptors
OBJECTIVE Hypothalamic tanycytes are glial cells that line the wall of the third ventricle and contact the cerebrospinal fluid (CSF). While they are known to detect glucose in the CSF we now show that tanycytes also detect amino acids, important nutrients that signal satiety. METHODS Ca2+ imaging and ATP biosensing were used to detect tanycyte responses to l-amino acids. The downstream pathwa...
متن کاملThyroid hormone activation of retinoic acid synthesis in hypothalamic tanycytes
Thyroid hormone (TH) is essential for adult brain function and its actions include several key roles in the hypothalamus. Although TH controls gene expression via specific TH receptors of the nuclear receptor class, surprisingly few genes have been demonstrated to be directly regulated by TH in the hypothalamus, or the adult brain as a whole. This study explored the rapid induction by TH of ret...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2014
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2014.01.008